HMB-45 vs. PRAME: How Do They Actually Stack Up?
A question I get from residents almost every week on the fellowship floor: “Do I still need HMB-45, or has PRAME made it obsolete?” The honest answer is neither stain replaces the other — they measure different things, and knowing why changes how you read your slides. How They Differ HMB-45 is a cytoplasmic/membranous marker…