Fundamentals Friday

Clear explanations of core concepts for beginners and anyone needing a refresher.

Fundamentals Friday

Clark’s Level vs. Breslow Thickness: Why Level III and IV Still Trip People Up
ByDiskssdadras September 4, 2026September 4, 2026

Category: Fundamentals Friday Clark’s Level vs. Breslow Thickness: Why Level III and IV Still Trip People Up Ask a resident to define Breslow thickness and you’ll usually get a confident, correct answer: a linear measurement, top of granular layer to deepest invasive cell, reported to the nearest 0.1 mm. Ask the same resident to explain…

Read More Clark’s Level vs. Breslow Thickness: Why Level III and IV Still Trip People Up
Fundamentals Friday

HMB-45 vs. PRAME: How Do They Actually Stack Up?
ByDiskssdadras August 17, 2026August 25, 2026

A question I get from residents almost every week on the fellowship floor: “Do I still need HMB-45, or has PRAME made it obsolete?” The honest answer is neither stain replaces the other — they measure different things, and knowing why changes how you read your slides. How They Differ HMB-45 is a cytoplasmic/membranous marker…

Read More HMB-45 vs. PRAME: How Do They Actually Stack Up?