Touton Giant Cell (Xanthelasmatic Giant Cell)

Compartment: Reticular Dermis

Illustration of a multinucleated giant cell with nuclei arranged in a wreath-like ring, separating a central eosinophilic core from an outer rim of foamy, lipid-laden cytoplasm.
Touton giant cell: wreath-like nuclear ring with eosinophilic core and foamy peripheral cytoplasm, seen in juvenile xanthogranuloma.

Definition: A multinucleated histiocyte with a wreath-like ring of nuclei separating an eosinophilic core from an outer rim of foamy cytoplasm — pathognomonic for juvenile xanthogranuloma.

Clinical Context: Juvenile xanthogranuloma, Xanthoma, Necrobiotic xanthogranuloma

Key Feature: Central wreath of nuclei encircling a homogeneous eosinophilic core, with a peripheral rim of pale, foamy (lipidized) cytoplasm.

🔗 Related Terms: Asteroid Body

See this in a real case: Checkpoint Inhibitor-Induced Interstitial Granulomatous Dermatitis →